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Last updated: June 10, 2025View editorial policy

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Differential Diagnosis for Epididymitis

  • Single most likely diagnosis
    • Epididymitis: This is the most likely diagnosis given the presentation, as it is a common condition characterized by inflammation of the epididymis, often caused by bacterial infection, and its symptoms align closely with what is typically observed in cases of epididymitis.
  • Other Likely diagnoses
    • Orchitis: Inflammation of one or both testicles, which can occur alongside epididymitis (epididymo-orchitis) and presents with similar symptoms such as testicular pain and swelling.
    • Testicular torsion: A condition that requires urgent medical attention, characterized by the twisting of the spermatic cord, cutting off the blood supply to the testicle. It presents with sudden, severe testicular pain.
    • Hydrocele: An accumulation of fluid in the tunica vaginalis, a potential space around the testicle, which can cause swelling and discomfort but is typically painless.
  • Do Not Miss (ddxs that may not be likely, but would be deadly if missed.)
    • Testicular cancer: Although less common, testicular cancer can present with a testicular mass or swelling and must be considered to ensure timely diagnosis and treatment.
    • Pyocele: An accumulation of pus in the tunica vaginalis, which can be a complication of epididymitis and requires prompt drainage.
    • Fournier's gangrene: A severe, life-threatening condition involving necrotizing fasciitis of the genitalia, which, although rare, demands immediate recognition and treatment.
  • Rare diagnoses
    • Spermatocele: A cystic structure filled with sperm, which is usually asymptomatic but can cause discomfort if large enough.
    • Varicocele: An enlargement of the veins within the scrotum, similar to varicose veins, which can cause a feeling of heaviness or discomfort but is typically not painful.
    • Tuberculosis epididymitis: A rare form of epididymitis caused by Mycobacterium tuberculosis, which can present with chronic symptoms and weight loss.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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