Differential Diagnosis for Pain in Smallest Three Toes with Burning in Pinky Toe

Single Most Likely Diagnosis

• Morton's Neuroma: This condition is characterized by a benign growth of nerve tissue in the ball of the foot, often causing pain, burning, or numbness in the toes, especially the third and fourth toes. The symptoms described, particularly the burning sensation in the pinky toe, align closely with Morton's Neuroma, making it a highly plausible diagnosis.

Other Likely Diagnoses

• Peripheral Neuropathy: This condition involves damage to the peripheral nerves and can cause pain, burning, or tingling sensations in the feet, including the toes. Diabetes, vitamin deficiencies, and alcohol abuse are common causes.
• Tarsal Tunnel Syndrome: Similar to carpal tunnel syndrome but affecting the foot, this condition involves compression of the posterior tibial nerve as it travels through the tarsal tunnel on the inner side of the ankle. Symptoms can include pain, numbness, and tingling in the toes.
• Toe Deformities (e.g., Hammertoes, Claw Toes): Abnormal positioning of the toes can lead to uneven distribution of weight and pressure, causing pain and discomfort, especially in the smaller toes.

Do Not Miss Diagnoses

• Deep Vein Thrombosis (DVT): Although less common, DVT can cause pain and swelling in the foot and should not be overlooked due to the risk of pulmonary embolism.
• Infection (e.g., Cellulitis, Abscess): Infections in the foot can cause significant pain and may be accompanied by redness, swelling, and warmth. Prompt diagnosis and treatment are crucial to prevent serious complications.
• Complex Regional Pain Syndrome (CRPS): A chronic pain condition that can follow an injury, CRPS is characterized by intense burning or aching pain in the affected limb, which in this case could be the foot.

Rare Diagnoses

• Erythromelalgia: A rare disorder characterized by burning pain, heat, and redness in the hands and feet, often occurring in response to heat or exercise.
• Fabry Disease: A genetic disorder that can cause burning pain in the hands and feet due to the accumulation of a particular type of fat in the body's cells.
• Sickle Cell Disease: While primarily known for causing anemia, sickle cell disease can also lead to episodes of pain, including in the feet, due to vaso-occlusive crises.