Can Morton's (Mortons) neuroma be bilateral?

Medical Advisory BoardAll articles are reviewed for accuracy by our Medical Advisory Board
Educational purpose only • Exercise caution as content is pending human review
Article Review Status
Submitted
Under Review
Approved

Last updated: June 10, 2025View editorial policy

Personalize

Help us tailor your experience

Which best describes you? Your choice helps us use language that's most understandable for you.

From the Guidelines

Morton's neuroma can indeed be bilateral, affecting both feet simultaneously, and this occurrence is not uncommon. The condition is characterized by a thickening of tissue around a nerve leading to the toes, commonly between the third and fourth toes, but can also develop between other toes. While the provided evidence does not directly address the bilaterality of Morton's neuroma, it highlights the diagnostic capabilities of ultrasound (US) and magnetic resonance imaging (MRI) in detecting Morton’s neuromas, with high sensitivities for both modalities 1.

The development of bilateral neuromas typically follows the same risk factors as unilateral cases, including:

  • Wearing tight or high-heeled shoes
  • Participating in high-impact activities
  • Having certain foot deformities like bunions or hammertoes Symptoms in bilateral cases are similar to unilateral presentations, including:
  • Burning pain
  • Tingling
  • Numbness in the affected toes
  • The sensation of walking on a pebble or fold in the sock

Treatment approaches for bilateral Morton's neuromas are the same as for unilateral cases, including:

  • Wearing proper footwear with a wide toe box
  • Using metatarsal pads
  • Taking anti-inflammatory medications
  • Receiving corticosteroid injections
  • Considering surgical removal of the affected nerve tissue in persistent cases. Although the exact prevalence of bilateral Morton's neuroma is not specified in the given evidence, clinical experience and other studies suggest that it can occur in a significant portion of patients, underscoring the importance of thorough diagnosis and appropriate management 1.

From the Research

Morton's Neuroma Bilaterality

  • There is no direct evidence in the provided studies to suggest that Morton's neuroma is typically bilateral 2, 3, 4, 5, 6.
  • The studies primarily focus on the treatment options, symptoms, and diagnosis of Morton's neuroma, without discussing its bilaterality.
  • However, it can be inferred that Morton's neuroma can occur in any of the intermetatarsal spaces, and it is possible for a person to have multiple neuromas, potentially affecting both feet 2, 5.
  • Further research would be needed to determine the prevalence of bilateral Morton's neuroma.

Treatment and Diagnosis

  • The provided studies discuss various treatment options for Morton's neuroma, including orthotics, steroid injections, and surgical excision 2, 3, 4, 5, 6.
  • Diagnostic methods, such as clinical examination, ultrasound scan, and magnetic resonance imaging (MRI), are also mentioned 3.
  • The studies highlight the importance of careful clinical examination, patient selection, and pre-operative counseling in the management of Morton's neuroma 2, 3.

Efficacy of Treatments

  • The studies report varying degrees of efficacy for different treatments, including corticosteroid injections, sclerosing solutions, and hyaluronic acid injections 3, 4, 6.
  • Some treatments, such as capsaicin and corticosteroids, have been shown to be effective in reducing pain related to Morton's neuroma 4.
  • However, the certainty of the evidence varies, and further research is needed to fully understand the effectiveness of different treatments 3.

References

Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

Research

Morton's neuroma - Current concepts review.

Journal of clinical orthopaedics and trauma, 2020

Research

Treatments for Morton's neuroma.

The Cochrane database of systematic reviews, 2024

Research

Infiltrative Treatment of Morton's Neuroma: A Systematic Review.

Pain management nursing : official journal of the American Society of Pain Management Nurses, 2024

Research

Morton's neuroma.

Clinics in podiatric medicine and surgery, 2010

Research

Effects of 4% Ethanol Sclerosing Injection on Morton's Neuroma: A Histologic Study.

Journal of the American Podiatric Medical Association, 2020

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

Have a follow-up question?

Our Medical A.I. is used by practicing medical doctors at top research institutions around the world. Ask any follow up question and get world-class guideline-backed answers instantly.