Is a 75 mg immediate‑release bupropion tablet available?

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Last updated: October 8, 2026 • View editorial policy

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75 mg Immediate-Release Bupropion Tablet Availability

No, there is no 75 mg immediate-release bupropion tablet commercially available in standard formulations. The evidence consistently shows that bupropion immediate-release formulations start at 100 mg as the lowest available dose 1.

Standard Bupropion Formulations and Dosing

Immediate-Release (IR) Formulation

  • Starting dose: 100 mg (not 75 mg)
  • Typical dosing: 100 mg three times daily, can be increased to 150 mg three times daily
  • Maximum daily dose: 450 mg per day 1

Sustained-Release (SR) Formulation

  • Starting dose: 100-150 mg once daily 2
  • Maintenance dose: 100-150 mg twice daily
  • Maximum daily dose: 400 mg per day 3

Extended-Release (XL) Formulation

  • Starting dose: 150 mg once daily 2
  • Maintenance dose: 150-300 mg once daily
  • Maximum daily dose: 450 mg per day 1

Special Combination Products

The only formulation containing a dose close to 75 mg is the naltrexone-bupropion ER combination tablet (Contrave), which contains 90 mg of bupropion (not 75 mg) combined with 8 mg naltrexone in each tablet 4. This is specifically formulated for obesity management, not as a standalone bupropion product.

Clinical Context

While research has documented the use of 75 mg doses in specific clinical scenarios (such as PRN dosing for SSRI-induced sexual dysfunction 5), and adverse effects have been reported with 75 mg doses 6, these do not represent commercially available tablet strengths. If a 75 mg dose is clinically indicated, it would require either:

  • Splitting a higher-dose immediate-release tablet (if scored)
  • Compounding by a pharmacy
  • Using alternative dosing strategies with available formulations

The standard commercially available immediate-release bupropion tablets begin at 100 mg, not 75 mg.

References

2
Guideline

attention-deficit/hyperactivity disorder in pregnancy and the postpartum period.

American Journal of Obstetrics and Gynecology, 2024

3
Guideline

smoking cessation, version 1.2016, nccn clinical practice guidelines in oncology.

Journal of the National Comprehensive Cancer Network : JNCCN, 2016

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This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.