From the Research
Taking urolithin-A and ashwagandha together may potentially have complementary anti-inflammatory effects, though research specifically on this combination is limited. Urolithin-A, a metabolite produced when gut bacteria process ellagitannins found in pomegranates and berries, has shown anti-inflammatory properties by activating mitophagy (removal of damaged mitochondria) and inhibiting inflammatory pathways, as demonstrated in a study published in the International Journal of Molecular Sciences 1. Ashwagandha, an adaptogenic herb, contains withanolides that have demonstrated anti-inflammatory effects by suppressing pro-inflammatory cytokines and NF-κB signaling pathways.
Key Findings
- Urolithin-A has been shown to inhibit the production of pro-inflammatory cytokines and reduce oxidative stress in various studies, including one published in Biomedicines in 2023 2.
- Ashwagandha has been found to have anti-inflammatory effects by suppressing pro-inflammatory cytokines and NF-κB signaling pathways.
- While each compound works through different mechanisms, their combined use might offer enhanced anti-inflammatory benefits.
Dosage and Administration
No standard dosage has been established for this combination, but typical supplemental doses are 250-1000mg for urolithin-A and 300-600mg of ashwagandha root extract daily. It is recommended to start with lower doses to assess tolerance, take with food to improve absorption, and consult a healthcare provider before beginning this regimen, especially if you have existing health conditions or take medications, as ashwagandha may interact with certain drugs including immunosuppressants, thyroid medications, and sedatives.
Mechanisms of Action
Urolithin-A and ashwagandha may work synergistically to reduce inflammation by inhibiting different pathways, including the NF-κB signaling pathway and the production of pro-inflammatory cytokines, as suggested by studies published in Phytomedicine in 2019 3 and Bioorganic & Medicinal Chemistry Letters in 2011 4. Additionally, urolithin-A has been shown to enhance mitophagy and mitochondrial function, which may also contribute to its anti-inflammatory effects, as discussed in a review published in Trends in Molecular Medicine in 2021 5.