From the Guidelines
The maximum recommended dose of Buspar (buspirone) is 60 mg per day, but according to the most recent and highest quality evidence available, the maximum dose is actually 20 mg three times daily, as stated in the guidelines for managing behavior and mood disorders 1.
Key Points to Consider
- The initial dosage of Buspar is 5 mg twice daily, and it may take 2 to 4 weeks to become effective 1.
- Buspar is useful only in patients with mild to moderate agitation, and it should be used with caution in patients with certain medical conditions.
- The dosage of Buspar should be adjusted based on individual response and tolerability, and it's essential to follow the healthcare provider's instructions to avoid any potential side effects.
Important Considerations
- Buspar is an anxiolytic drug that works by affecting certain chemicals in the brain, primarily serotonin and dopamine.
- Side effects of Buspar are generally mild but may include dizziness, headache, and nausea, especially when first starting the medication or increasing the dose.
- It's crucial to monitor patients for any adverse reactions and adjust the dosage accordingly to ensure the best possible outcome in terms of morbidity, mortality, and quality of life.
From the FDA Drug Label
In clinical pharmacology trials, doses as high as 375 mg/day were administered to healthy male volunteers. The maximum dose of Buspar (buspirone) is not explicitly stated in the drug label as a recommended dose, but 375 mg/day was the highest dose administered in clinical trials.
- The drug label does not provide a maximum recommended dose.
- Doses up to 375 mg/day have been administered in clinical trials, but this does not necessarily imply that this is the recommended maximum dose. 2
From the Research
Maximum Dose of Buspar (Buspirone)
- The maximum dose of Buspar (buspirone) is not explicitly stated in the provided studies 3, 4, 5, 6, 7.
- However, the studies mention various dosing regimens, including:
- The pharmacokinetics of buspirone are linear over the dose range 10 to 40 mg 5, suggesting that higher doses may be tolerated, but the maximum recommended dose is not specified.
- It is essential to consult the prescribing information or a healthcare professional for guidance on the maximum dose of Buspar (buspirone) 3, 4, 5, 6, 7.