Anusol Suppository Dosage
For adults with nonspecific proctitis, use one Anusol-HC suppository (25 mg hydrocortisone acetate) rectally in the morning and at night for two weeks 1.
Standard Dosing Regimen
The FDA-approved dosing for Anusol-HC suppositories is straightforward 1:
- Mild to moderate cases (nonspecific proctitis): 1 suppository rectally twice daily (morning and night) for 2 weeks
- More severe cases: 1 suppository three times daily, OR 2 suppositories twice daily
- Factitial proctitis: Continue therapy for 6-8 weeks or less, depending on clinical response
Administration Instructions
Each suppository contains 25 mg of hydrocortisone acetate in a hydrogenated vegetable oil base 1. The suppositories are designed to melt at body temperature, so minimize handling 1:
- Separate the plastic film at the top opening and pull downward
- Continue pulling to almost the full length of the suppository
- Gently remove from the film pocket and insert rectally
Storage Requirements
Store at room temperature (20-25°C or 68-77°F) away from heat and protect from freezing 1.
Clinical Context
While the BSG guidelines discuss intravenous hydrocortisone 100 mg four times daily for acute severe ulcerative colitis requiring hospitalization 2, this is a completely different clinical scenario and route of administration than topical rectal suppositories for localized anorectal conditions. The suppository formulation is intended for local anti-inflammatory effects in the rectal area, not systemic treatment of severe inflammatory bowel disease.
Common Pitfall
Do not confuse the dosing of rectal suppositories (25 mg per suppository, 1-2 suppositories daily) with intravenous hydrocortisone dosing used in hospitalized patients with severe systemic disease (100 mg IV four times daily). These are entirely different formulations, routes, and clinical indications.