There are no official guidelines to assist in answering this question. I will search for relevant research papers instead.
The FDA Drug Labels for adapalene (TOP), benzoyle peroxide (TOP) do not address this question.
From the Research
Dosing Frequency for Adapalene/Benzoyl Peroxide
The dosing frequency for adapalene/benzoyl peroxide is:
- Once daily, as indicated in studies 1, 2, 3, 4 Some key points about the dosing frequency include:
- A unique, once-daily, fixed-dose combination gel with adapalene 0.1% and benzoyl peroxide 2.5% has been developed for the treatment of acne vulgaris 1
- The fixed-dose combination adapalene 0.1%/benzoyl peroxide 2.5% is indicated for the once-daily topical treatment of Acne vulgaris when comedones, papules and pustules are present 2
- Patients received adapalene-BPO once daily in the studies 1, 2, 3, 4
Efficacy and Safety
The efficacy and safety of adapalene/benzoyl peroxide have been evaluated in several studies, including:
- A 12-month study that found early and sustained reductions in inflammatory and noninflammatory lesions, with clinically significant lesion reductions as early as week 1 1
- A non-interventional study that found significant improvements in acne severity and treatment success, with a low rate of adverse events 2
- A randomized controlled trial that found the fixed-dose combination of adapalene and benzoyl peroxide to be significantly more effective than corresponding monotherapies, with a comparable safety profile to adapalene 3