From the Research
Muted orgasms after discontinuing Latuda (lurasidone) could be due to post-acute withdrawal syndrome, where the brain is still adjusting to functioning without the medication. Even with normal prolactin and serotonin levels, neurotransmitter systems like dopamine may still be recalibrating, affecting sexual function. This adjustment period typically lasts weeks to months. Other potential causes include underlying depression or anxiety that was previously masked by medication, stress, relationship factors, or other medications you might be taking. To address this issue, give your body more time to readjust, practice mindfulness techniques during intimacy, consider using lubricants if experiencing vaginal dryness, and maintain open communication with your partner. If symptoms persist beyond 3-6 months, consult with a healthcare provider who specializes in sexual health or a psychiatrist familiar with medication effects. They might recommend specific therapies or adjustments to any current medications, such as bupropion, which has been shown to have a positive effect on sexual function in some individuals 1, 2. The brain's neurochemistry is complex, and sexual function involves multiple neurotransmitters and hormonal systems beyond just serotonin and prolactin. Some studies suggest that bupropion may be an effective treatment for sexual dysfunction, particularly in individuals with depression or anxiety 1, 2. However, it is essential to consult with a healthcare provider before starting any new medication or therapy. In the context of your situation, where prolactin and serotonin levels are normal, the focus should be on addressing potential underlying issues such as post-acute withdrawal syndrome, depression, or anxiety, and exploring therapies that can help mitigate these effects. It is also crucial to maintain open communication with your partner and consider seeking professional help if symptoms persist. Ultimately, the goal is to improve your quality of life and sexual function, and a healthcare provider can help you navigate the best course of treatment.