What is the recommended dose of Flonase (fluticasone propionate)?

From the Guidelines

The recommended dose of Flonase (fluticasone propionate) is 1 spray per nostril every day for children aged 4 and above, and 2 sprays per nostril every day for adults. This dosage is based on the clinical practice guideline for allergic rhinitis, as outlined in the study published in 2015 1.

Key Considerations

• The dosage for Flonase is specified as 50 µg per spray, and it is approved for use in children aged 4 and above.
• The medication is available by prescription and is used to treat allergic rhinitis and nonallergic rhinitis.
• Common side effects of Flonase include headache, pharyngitis, epistaxis, nasal burning or irritation, nausea or vomiting, asthma symptoms, and cough.

Administration Instructions

• Before first use, the bottle should be primed by pumping until a fine mist appears.
• If the spray hasn't been used for a week or more, prime again with 1 spray.
• For best results, use Flonase at the same time each day, and it may take several days (up to a week) to feel the full benefit.

Mechanism of Action

• Flonase works by reducing inflammation in the nasal passages, which helps relieve symptoms of allergic rhinitis such as sneezing, itching, runny nose, and nasal congestion.
• The medication should be used regularly as prescribed, even when symptoms improve, to maintain control of nasal symptoms.

From the FDA Drug Label

DOSAGE AND ADMINISTRATION Patients should use Fluticasone Propionate Nasal Spray, USP, at regular intervals for optimal effect. Adults The recommended starting dosage in is 2 sprays (50 mcg of fluticasone propionate each) in each nostril once daily (total daily dose, 200 mcg). The same dosage divided into 100 mcg given twice daily (e.g., 8 a.m. and 8 p.m.) is also effective. After the first few days, patients may be able to reduce their dosage to 100 mcg (1 spray in each nostril) once daily for maintenance therapy. Patients should be started with 100 mcg (1 spray in each nostril once daily). Patients not adequately responding to 100 mcg may use 200 mcg (2 sprays in each nostril). Once adequate control is achieved, the dosage should be decreased to 100 mcg (1 spray in each nostril) daily The maximum total daily dosage should not exceed 2 sprays in each nostril (200 mcg/day).

The recommended dose of Flonase (fluticasone propionate) is:

• Adults: 2 sprays (50 mcg each) in each nostril once daily (total daily dose, 200 mcg) or 100 mcg given twice daily.
• Adolescents and Children (4 Years of Age and Older): 100 mcg (1 spray in each nostril) once daily, which may be increased to 200 mcg (2 sprays in each nostril) if needed.
• Maximum daily dose: 2 sprays in each nostril (200 mcg/day) 2.

From the Research

Flonase Dose Information

• The recommended dose of Flonase (fluticasone propionate) is not explicitly stated in the provided studies.
• However, the studies discuss the efficacy and safety of fluticasone propionate in the treatment of allergic rhinitis, with some studies comparing it to other treatments such as azelastine and antihistamines 3, 4, 5, 6, 7.
• The studies suggest that fluticasone propionate is an effective treatment for allergic rhinitis, with some studies showing it to be superior to other treatments in reducing symptom scores 4, 6, 7.
• The dosage of fluticasone propionate is not specified in the provided studies, but it is likely that the recommended dose is similar to that of other intranasal corticosteroids, which are typically used once or twice daily.

Treatment of Allergic Rhinitis

• Allergic rhinitis is a common condition that can be treated with a variety of medications, including intranasal corticosteroids, antihistamines, and combination therapies 3, 4, 5, 6, 7.
• The choice of treatment depends on the severity of symptoms, patient preferences, and other factors, with intranasal corticosteroids such as fluticasone propionate often recommended as first-line treatment for moderate to severe allergic rhinitis 4, 6.
• Combination therapies, such as the combination of azelastine and fluticasone propionate, may also be effective in reducing symptom scores and improving quality of life for patients with allergic rhinitis 7.