From the Research
The effectiveness of dimethylaminoethanol (DMAE) for anti-aging is not well-supported by strong scientific evidence. While DMAE is marketed in many topical creams and oral supplements with claims of reducing wrinkles, firming skin, and improving cognitive function, research supporting these benefits is limited and often of poor quality 1, 2, 3. DMAE is thought to work by potentially stabilizing cell membranes and acting as a precursor to acetylcholine, which might temporarily tighten facial muscles. Typical formulations include 3-5% DMAE in topical creams applied once or twice daily, or oral supplements ranging from 100-400mg daily.
Some key points to consider when evaluating the use of DMAE for anti-aging include:
- The lack of high-quality clinical trials supporting its effectiveness for anti-aging benefits
- The potential for side effects, such as skin irritation with topical use or headaches, insomnia, and muscle tension with oral supplements
- The availability of alternative anti-aging treatments with stronger scientific backing, including retinoids, vitamin C serums, sunscreen, and peptide formulations
It's also important to consider the principles of evidence-based practice, which involve basing clinical decisions on the best available evidence, as discussed in 1 and 2. In the context of DMAE for anti-aging, this means prioritizing treatments with stronger scientific evidence and being cautious when using products with limited or poor-quality research support. As noted in 3, clinical decision-making should be based on the synthesis of evidence-based medicine, sound clinical judgment, and guidelines.
Given the current state of evidence, it is recommended to approach the use of DMAE for anti-aging with caution and to consult with a healthcare provider before using DMAE products, especially oral supplements, as the long-term safety profile remains unclear. Instead, consider alternative anti-aging treatments with stronger scientific backing, such as retinoids, vitamin C serums, sunscreen, and peptide formulations, as discussed in the examples provided. Additionally, vitamins like vitamin A and vitamin E, which have been studied for their antioxidant properties, may be considered as part of a comprehensive anti-aging strategy, as noted in 4.