From the Research
Cyproterone for transgender testosterone suppression can typically be taken continuously for several years under medical supervision, without a mandatory break, with the recommended duration usually being 2-5 years, as supported by the most recent study 1. The usual dose for transgender hormone therapy is 10-25 mg daily, as lower doses have been shown to be equally effective in lowering testosterone concentrations while minimizing side effects, such as changes in liver enzyme concentrations and increases in prolactin concentrations 1, 2. Key considerations for cyproterone therapy include:
- Regular monitoring of liver function, hormone levels, and overall health through blood tests every 3-6 months
- Potential side effects, including liver toxicity, depression, and a slight increase in the risk of certain tumors
- The importance of a comprehensive hormone therapy plan, tailored to the individual's needs and health status
- The possibility of transitioning to other forms of hormone therapy or undergoing gender-affirming surgery after 2-5 years, or when testosterone suppression goals are achieved Some patients may be able to reduce the dose or switch to other medications like GnRH analogues, with this transition being gradual and supervised by a healthcare provider 3, 4. It's crucial to note that cyproterone use should always be part of a comprehensive hormone therapy plan, with regular check-ups and open communication with a healthcare provider being essential for optimizing treatment and minimizing risks.