From the FDA Drug Label
Although the rate of valproate ion absorption may vary with the formulation administered (liquid, solid, or sprinkle), conditions of use (e.g., fasting or postprandial) and the method of administration (e.g., whether the contents of the capsule are sprinkled on food or the capsule is taken intact), Co-administration of oral valproate products with food and substitution among the various divalproex sodium and valproic acid formulations should cause no clinical problems in the management of patients with epilepsy
The Depakote sprinkles can be mixed with food and consumed. However, the label does not explicitly state that it can be mixed with water. Therefore, it is recommended to follow the instructions provided by the healthcare provider or the manufacturer for the administration of Depakote sprinkles. 1
From the Research
Yes, Depakote (valproate) sprinkles can be mixed with a small amount of water and consumed, but this should be done immediately after mixing. The sprinkles are designed to be opened and sprinkled onto soft food like applesauce or pudding, and they can also be mixed with a small amount of water 2. It's essential not to crush or chew the sprinkles as this would damage the special coating that controls how the medication is released in your body. When mixing with water, use only a small amount (about a tablespoon) and consume the entire mixture right away to ensure you get the full dose. The sprinkles contain tiny beads of medication that are coated to help protect your stomach and control the release rate of the medication. This formulation is particularly helpful for people who have difficulty swallowing pills while still maintaining the effectiveness of the medication for treating seizures, bipolar disorder, or migraines. Some key points to consider when taking Depakote sprinkles include:
- The medication should be taken as directed by your doctor, and the dosage should not be changed without consulting them 3.
- Valproate has a broad spectrum of anticonvulsant activity and is effective against various seizure types, including absence, myoclonic, and generalized tonic-clonic seizures 2.
- The medication can cause side effects, such as gastrointestinal disturbances, tremor, and body weight gain, so it's crucial to monitor your condition and report any concerns to your doctor 3. It's also important to note that valproate is extensively metabolized by microsomal glucuronide conjugation, mitochondrial beta-oxidation, and cytochrome P450-dependent omega-, (omega-1)-, and (omega-2)-oxidation, and its elimination half-life is around 9 to 18 hours 3. Overall, Depakote sprinkles can be a convenient and effective way to take valproate, but it's essential to follow the instructions and consult with your doctor if you have any questions or concerns.