Generic Name for Caplyta
The generic name for Caplyta is lumateperone 1.
Medication Details
Caplyta capsules contain lumateperone, which is present as the tosylate salt (lumateperone tosylate) 1. The chemical name is 4-((6bR,10aS)-3-methyl-2,3,6b,9,10,10a-hexahydro-1H,7H-pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxalin-8-yl)-1-(4-fluoro-phenyl)-butan-1-one 4-methylbenzenesulfonate 1.
Available Strengths
Lumateperone is available in three strengths 1:
- 42 mg (equivalent to 60 mg lumateperone tosylate)
- 21 mg (equivalent to 30 mg lumateperone tosylate)
- 10.5 mg (equivalent to 15 mg lumateperone tosylate)
FDA-Approved Indications
Lumateperone received FDA approval for 2:
- Schizophrenia in adults (December 2019)
- Bipolar depression (depressive episodes associated with bipolar I or II disorder) (2021)
The medication is classified as an atypical antipsychotic with a novel mechanism that simultaneously modulates serotonin, dopamine, and glutamate neurotransmission 3.