Yes, you can take amoxicillin-clavulanate while on Jardiance (empagliflozin)
There are no known drug interactions between amoxicillin-clavulanate and empagliflozin, and these medications can be safely taken together without dose adjustments.
Drug Interaction Profile
The FDA label for Jardiance does not list amoxicillin-clavulanate as a contraindicated or cautionary medication 1. Research specifically examining empagliflozin's drug interaction profile has focused on medications metabolized through cytochrome P450 pathways (such as warfarin), and empagliflozin showed no clinically significant interactions even with these drugs 2.
Amoxicillin-clavulanate is not metabolized through pathways that would interact with empagliflozin's mechanism of action (SGLT2 inhibition in the renal tubules). The antibiotic works systemically to treat bacterial infections, while empagliflozin works specifically in the kidney to block glucose reabsorption.
Important Monitoring Considerations
While taking both medications together:
Stay well-hydrated: Both empagliflozin and infections can increase dehydration risk. Empagliflozin causes osmotic diuresis (increased urination), and if you're taking amoxicillin-clavulanate for an infection, you may already be at risk for volume depletion 3, 1.
Watch for genital/urinary infections: Empagliflozin increases the risk of mycotic genital infections and urinary tract infections 3, 1. If you're being treated for a urinary or genital infection with amoxicillin-clavulanate, this is particularly relevant to monitor.
Monitor blood glucose if diabetic: If you have diabetes and are taking Jardiance for glycemic control, illness and antibiotics can affect blood sugar levels independently of any drug interaction.
Common Pitfalls to Avoid
Do not stop taking Jardiance while on antibiotics unless specifically instructed by your physician. The cardiovascular and renal protective benefits of empagliflozin continue even during acute illnesses 4, 5.
If you develop diarrhea from amoxicillin-clavulanate (a common side effect occurring in approximately 15% more patients than with amoxicillin alone 6), increase fluid intake to compensate for both the antibiotic side effect and empagliflozin's diuretic effect.