Key Information
Cisatracurium besylate is the generic name for this non-depolarizing neuromuscular blocking agent. The drug is available as:
- Nimbex® (brand name, manufactured by Glaxo-Wellcome) 3
- Various generic formulations (e.g., Cisatrex®) 2
Clinical Context
Cisatracurium is one of 10 stereoisomers of atracurium besylate and constitutes approximately 15% of the atracurium mixture 1. It is classified as an intermediate-acting benzylisoquinoline muscle relaxant with several advantageous properties:
- Organ-independent elimination via Hofmann degradation, making it particularly suitable for patients with renal or hepatic failure 4
- Higher potency than atracurium, resulting in lower doses and reduced laudanosine generation 4
- Minimal histamine release and cardiovascular effects 3, 5
The FDA-approved formulation is supplied as Cisatracurium Besylate Injection, USP in concentrations of 2 mg/mL (for general use) and 10 mg/mL (for ICU use only) 1.