From the Research
Sermorelin works by mimicking the action of naturally occurring growth hormone-releasing hormone (GHRH) in the body, stimulating the release of growth hormone from the anterior pituitary gland. When administered, sermorelin binds to GHRH receptors on cells called somatotrophs in the anterior pituitary gland. This binding activates these cells to synthesize and release growth hormone (GH) into the bloodstream. Importantly, sermorelin preserves the body's natural pulsatile pattern of GH release rather than creating constantly elevated levels. The released growth hormone then acts on various tissues throughout the body, particularly the liver, where it stimulates the production of insulin-like growth factor-1 (IGF-1) 1. Together, GH and IGF-1 promote effects such as increased protein synthesis, enhanced fat metabolism, improved cell regeneration, and tissue growth. Unlike direct GH administration, sermorelin only stimulates the body's own production of growth hormone when physiologically appropriate, which helps maintain normal negative feedback mechanisms and reduces the risk of side effects associated with excessive GH levels.
Some key points to consider about sermorelin include:
- It is a 29 amino acid analogue of human growth hormone-releasing hormone (GHRH) with full biological activity of GHRH 2
- Sermorelin is typically administered as a subcutaneous injection at doses of 100-500 mcg daily, usually before bedtime to align with the body's natural GH release patterns
- The effects of sermorelin on growth hormone release and subsequent IGF-1 production are well-documented, with benefits including improved body composition, enhanced muscle mass and strength, and better quality of life 3, 4
- Sermorelin has been shown to be effective in treating children with idiopathic growth hormone deficiency, with significant increases in height velocity and catch-up growth observed in the majority of patients 2
Overall, sermorelin is a well-tolerated and effective treatment option for growth hormone deficiency, offering a more natural approach to stimulating growth hormone release compared to direct GH administration. As with any medical treatment, it is essential to carefully consider the potential benefits and risks of sermorelin therapy and to monitor patients closely for any adverse effects.