What are the symptoms associated with a 16 mm Tarlov (perineural) cyst?

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Last updated: October 13, 2026 • View editorial policy

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Symptoms of a 16mm Tarlov Cyst

A 16mm Tarlov cyst commonly causes lower back pain, lower extremity radiculopathy, positional pain (worsening with sitting/standing), and urogenital dysfunction including urinary urgency, frequency, and bladder/bowel dysfunction.

Primary Symptom Profile

Based on the most recent research evidence, patients with Tarlov cysts of this size typically present with:

Pain Symptoms

  • Lower back pain (83% of patients) - the most common presenting symptom 1
  • Lower extremity radiculopathy (75% of patients) - pain radiating down the legs following sacral nerve root distributions 1
  • Positional pain (62% of patients) - characteristically worsens with sitting and standing, improves when lying prone 1, 2
  • Buttock pain - often persistent even after surgical intervention 2

Urogenital Dysfunction

At 16mm, the cyst size correlates with increased urinary dysfunction 1:

  • Urinary urgency (54% of patients) 1
  • Urinary frequency (48% of patients) 1
  • Bladder dysfunction - including urinary incontinence 3, 4
  • Bowel dysfunction - constipation and fecal incontinence 3, 5
  • Sexual dysfunction - including persistent genital arousal disorder and genito-pelvic dysesthesia 6

Neurological Symptoms

  • Saddle paresthesia - numbness in the perineal region 3
  • Motor impairment of lower limbs - muscle atrophy and weakness from ventral motor root compression 4
  • Cauda equina syndrome - when multiple nerve roots are compressed 4

Size-Specific Considerations

The 16mm size is clinically significant - research demonstrates that larger cyst size specifically correlates with urinary dysfunction (P = 0.05), while smaller cysts more commonly cause early sensation of filling 1. At 16mm, this cyst falls into the range where symptoms are more likely to be present and potentially disabling.

Location Matters

Tarlov cysts are most commonly located at S2-S3 (73% of cases) 1. The specific sacral level affects symptom presentation:

  • S2 location correlates with central nervous system symptoms (P = 0.02) 1
  • Cysts at S3-S4 typically cause leg and buttock pain 2

Urodynamic Findings

When urogenital symptoms are present, objective findings include 1:

  • Early sensation of filling (70%)
  • Involuntary detrusor contractions (33%)
  • Urethral instability (33%)
  • Stress urinary incontinence (33%)

These rates are significantly higher than the general population, confirming the clinical impact of symptomatic Tarlov cysts.

Important Clinical Pitfalls

Do not dismiss symptoms as unrelated - even when cysts are discovered incidentally, they should be documented as they may become symptomatic later 4. The characteristic positional nature of pain (worse with sitting/standing, better prone) is a key diagnostic clue that distinguishes Tarlov cyst pain from other causes 1, 2.

Recognize that 90% of patients are women, and connective tissue disorders like Ehlers-Danlos syndrome significantly increase risk 4. This demographic pattern should raise clinical suspicion when evaluating pelvic or sacral symptoms in female patients.

When Cysts Are Asymptomatic

Most small Tarlov cysts remain asymptomatic and require no treatment 4, 7. However, at 16mm, this cyst is large enough to warrant clinical correlation with symptoms, as size correlates with likelihood of urinary dysfunction 1.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.