How to Write a Prescription for Kyleena
Write the prescription as: "Kyleena (levonorgestrel-releasing intrauterine system) 19.5 mg - 1 sterile unit - for intrauterine insertion" with instructions that it must be inserted by a trained healthcare provider. 1
Prescription Components
The prescription should include the following specific elements based on FDA labeling:
- Drug name: Kyleena (levonorgestrel-releasing intrauterine system)
- Strength: 19.5 mg levonorgestrel total content
- Quantity: 1 sterile unit
- Route: Intrauterine use
- Special instruction: "To be inserted in the uterus by or under the supervision of a licensed clinician" 1
Key Prescribing Details
This is NOT a patient-administered device. The prescription is essentially an order for the device to be available for insertion by you or another trained provider. The patient cannot self-insert this device.
Important Prescribing Notes:
- Duration of use: Approved for up to 5 years of contraceptive protection 1
- Release rate: Starts at 17.5 mcg/day after 24 days, declining to 7.4 mcg/day by year 5 1
- Follow-up: Schedule patient for re-examination 4-6 weeks post-insertion, then yearly 1
Clinical Context for Insertion Timing
When writing the prescription, consider timing of insertion based on 2024 CDC guidelines:
- If ≤7 days after menses start: No backup contraception needed 2
- If >7 days after menses start: Advise 7 days of backup contraception 2
- When switching from another method: May need 7 days backup depending on prior method 2
Common Pitfall
Do not write this as a traditional "take as directed" prescription. This is a medical device that requires provider insertion using strict aseptic technique. The prescription serves as authorization to obtain the device for a scheduled insertion procedure, not for patient pickup and self-administration.
The actual insertion must follow the detailed instructions provided with the device and requires training in IUD placement technique 1.