What is the cause of vomiting with elevated liver enzymes (transaminitis)?

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Last updated: February 24, 2025View editorial policy

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Differential Diagnosis for Vomiting with Transaminitis

  • Single Most Likely Diagnosis
    • Viral hepatitis: This is a common cause of transaminitis and can lead to vomiting due to the systemic effects of the infection.
  • Other Likely Diagnoses
    • Gastroenteritis: Inflammation of the stomach and intestines can cause vomiting and elevated liver enzymes due to the systemic response to infection.
    • Medication-induced liver injury: Many medications can cause liver damage, leading to transaminitis, and may also cause vomiting as a side effect.
    • Alcoholic liver disease: Excessive alcohol consumption can lead to liver damage, causing transaminitis and vomiting.
  • Do Not Miss Diagnoses
    • Acetaminophen overdose: This is a medical emergency that can cause severe liver damage and transaminitis, often presenting with vomiting.
    • Budd-Chiari syndrome: A rare condition where blood clots form in the hepatic veins, causing liver damage and potentially life-threatening complications if not promptly treated.
    • Wilson's disease: A genetic disorder that can cause liver damage and neurological symptoms, requiring early diagnosis and treatment to prevent long-term damage.
  • Rare Diagnoses
    • Autoimmune hepatitis: A chronic condition where the immune system attacks the liver, causing inflammation and damage.
    • Primary biliary cholangitis: A chronic liver disease that causes progressive damage to the bile ducts, leading to liver damage and potentially cirrhosis.
    • Hemochromatosis: A genetic disorder that causes excessive iron absorption, leading to liver damage and potentially other systemic complications.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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