Generic Name for Belsomra
The generic name for Belsomra is suvorexant 1.
Drug Classification and Mechanism
Suvorexant is a dual orexin receptor antagonist (DORA), the first medication in this class approved by the FDA 2. It works by blocking orexin receptors OX1R and OX2R, which suppresses the wake-promoting signals in the brain 1.
Available Formulations
Suvorexant (Belsomra) is available as oral tablets in the following strengths 1:
- 5 mg
- 10 mg
- 15 mg
- 20 mg
The FDA-approved dosing is 20 mg for non-elderly patients and 15 mg for elderly patients 3.
Clinical Context
Suvorexant was approved in the United States in August 2014 for the treatment of insomnia characterized by difficulties with sleep onset and/or sleep maintenance 1, 2. It represents a novel mechanism of action compared to traditional hypnotics like benzodiazepines and Z-drugs, as it promotes sleep by blocking wakefulness signals rather than enhancing sedation 4.