Generic Name for Lunesta
The generic name for Lunesta is eszopiclone 1.
Drug Classification and Chemical Structure
Eszopiclone is a nonbenzodiazepine hypnotic agent classified as a benzodiazepine receptor agonist (BZD receptor agonist). Specifically, it is the S-enantiomer (single isomer) of racemic zopiclone, belonging to the pyrrolopyrazine derivative of the cyclopyrrolone class 1, 2.
Clinical Context
The American Academy of Sleep Medicine guidelines recommend eszopiclone for treatment of both sleep onset and sleep maintenance insomnia in adults, with evidence supporting 2 mg and 3 mg doses 3. The medication is formulated as film-coated tablets available in 1 mg, 2 mg, and 3 mg strengths 1.
Key Distinguishing Features:
- Chemical name: (+)-(5S)-6-(5-chloropyridin-2-yl)-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b] pyrazin-5-yl 4-methylpiperazine-1-carboxylate
- Molecular weight: 388.81
- Empirical formula: C17H17ClN6O3
- Physical properties: White to light-yellow crystalline solid, very slightly soluble in water 1
The drug is marketed under the brand name Lunesta in the United States and was previously known as Estorra during development 2. It is classified as a federally controlled substance (Schedule C-IV) due to potential for abuse or dependence 1.