From the Guidelines
Tinea infections should be treated with oral antifungal medications, such as terbinafine or griseofulvin, as topical therapy alone is not recommended for the treatment of tinea capitis, and oral therapy is generally indicated to achieve both clinical and mycological cure 1.
Treatment Overview
The choice of systemic therapy should be directed by the causative dermatophyte and/or local epidemiology, with terbinafine being more efficacious against Trichophyton species and griseofulvin more effective against Microsporum species 1.
- For children under 50 kg, the recommended dose of griseofulvin is 15-20 mg/kg per day for 6-8 weeks, while for those over 50 kg, the dose is 1 g per day for 6-8 weeks 1.
- For terbinafine, the dose varies by body weight:
- Less than 20 kg: 625 mg per day for 2-4 weeks
- 20-40 kg: 125 mg per day for 2-4 weeks
- Over 40 kg: 250 mg per day for 2-4 weeks 1.
Considerations for Treatment
It is essential to consider the potential for treatment failure, which may be due to lack of compliance, suboptimal absorption of the drug, relative insensitivity of the organism, or reinfection 1.
- In cases of clinical improvement but ongoing positive mycology, continuing the current therapy for a further 2-4 weeks is recommended 1.
- If there has been no initial clinical improvement, proceeding to second-line therapy, such as itraconazole, may be necessary 1.
Additional Measures
Children receiving appropriate therapy should be allowed to attend school or nursery, and index cases due to T. tonsurans warrant screening of all family members and close contacts, with treatment for those positive cases 1.
- The end point of treatment is mycological rather than clinical cure, and repeat mycology sampling is recommended until mycological clearance is achieved 1.
From the Research
Tineas Treatment
The provided studies do not directly address the treatment of Tineas, a fungal infection. However, we can explore some general information about fungal infections and their treatment.
- Fungal infections, such as Tineas, are typically treated with antifungal medications.
- The treatment approach may vary depending on the severity and location of the infection.
- Some common antifungal medications used to treat fungal infections include topical creams, oral medications, and in severe cases, intravenous medications.
Related Studies
While the provided studies do not directly address Tineas treatment, they discuss inflammation and immune responses, which can be related to fungal infections. For example:
- A study on the role of inflammation in autoimmune disease 2 highlights the importance of understanding the immune system's response to infections.
- Another study on a hybrid mutual prodrug of ibuprofen and acetaminophen 3 discusses its potential anti-inflammatory effects, which could be relevant to treating inflammatory responses associated with fungal infections.
- A review on autoinflammatory diseases 4 provides insight into the complex pathophysiology of these conditions, which may be related to fungal infections.
- A study on non-steroidal anti-inflammatory drugs (NSAIDs) and organ damage 5 discusses the potential risks and benefits of using NSAIDs, which may be used to treat pain and inflammation associated with fungal infections.
Treatment Options
Although the provided studies do not directly address Tineas treatment, antifungal medications are typically used to treat fungal infections. It is essential to consult a healthcare professional for proper diagnosis and treatment.