There are no official guidelines to assist in answering this question. I will search for relevant research papers instead.
From the FDA Drug Label
If accidental ingestion occurs, seek medical attention immediately Overdosage resulting in death may occur in adults. Signs and symptoms of overdose have been reported within 15-20 minutes and death has been reported within one hour of ingestion. Signs and symptoms may include restlessness, tremors, convulsions, coma and cardiac arrest.
The treatment for benzonatate toxicity is to seek medical attention immediately if accidental ingestion occurs.
- Key symptoms of overdose may include:
- Restlessness
- Tremors
- Convulsions
- Coma
- Cardiac arrest 1
From the Research
Treatment for Benzonatate Toxicity
The treatment for benzonatate toxicity is primarily supportive in nature, as evidenced by the studies 2, 3, 4, 5, 6. The following are some of the treatments that have been reported:
- Intubation: This is a common treatment for benzonatate toxicity, as it helps to secure the airway and prevent further complications 2, 4.
- Cardiopulmonary resuscitation (CPR): CPR is often necessary in cases of benzonatate toxicity, as the drug can cause cardiac arrest 2, 3, 4.
- Vasopressors: These medications are used to support blood pressure and cardiac function in patients with benzonatate toxicity 2.
- Gastric lavage: This procedure may be performed to remove the drug from the stomach and prevent further absorption 3.
- Activated charcoal: This is sometimes administered to help absorb the drug and reduce its toxicity 3.
- Hypothermia protocol: This may be initiated in some cases to help reduce the risk of brain damage and other complications 4.
Supportive Care
Supportive care is critical in the management of benzonatate toxicity, as the drug can cause a range of symptoms, including:
- Seizures: These can be treated with anticonvulsant medications and supportive care 2, 3, 5.
- Cardiac arrhythmias: These can be treated with anti-arrhythmic medications and supportive care 2, 3, 4.
- Metabolic acidosis: This can be treated with supportive care, including fluid resuscitation and electrolyte management 4, 5.
- Respiratory failure: This can be treated with supportive care, including oxygen therapy and mechanical ventilation 2, 4.