Is the shingles vaccination (Shingrix, herpes zoster vaccine) effective in improving memory?

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Last updated: June 11, 2025View editorial policy

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From the Guidelines

No, the shingles vaccination (Shingrix or herpes zoster vaccine) is not effective in improving memory. The vaccine is specifically designed to prevent shingles (herpes zoster), a painful rash caused by reactivation of the varicella-zoster virus that causes chickenpox. The vaccine works by boosting your immune system's ability to protect you against the virus, but it has no known effects on cognitive function or memory. Shingrix is typically administered as a two-dose series, with the second dose given 2-6 months after the first, to adults 50 years and older. While some vaccines are being researched for potential cognitive benefits, particularly in older adults, the shingles vaccine has not demonstrated any memory-enhancing properties in clinical studies 1. If you're concerned about memory issues, it would be more appropriate to discuss this with your healthcare provider, who can recommend evidence-based approaches for cognitive health, such as physical exercise, mental stimulation, proper nutrition, and management of cardiovascular risk factors. Key points to consider:

  • The shingles vaccine is designed to prevent shingles, not improve memory
  • The vaccine has no known effects on cognitive function or memory
  • Shingrix is administered as a two-dose series to adults 50 years and older
  • Evidence-based approaches for cognitive health should be discussed with a healthcare provider.

From the Research

Shingles Vaccination and Memory

  • There is no direct evidence to suggest that the shingles vaccination (Shingrix, herpes zoster vaccine) is effective in improving memory 2, 3, 4, 5, 6.
  • The studies primarily focus on the vaccine's effectiveness in preventing herpes zoster (shingles) and its associated complications, such as postherpetic neuralgia 2, 3, 4, 5.
  • The vaccines, including LZV (live attenuated zoster vaccine) and RZV (recombinant zoster vaccine), have been shown to be effective in preventing shingles, with vaccine effectiveness ranging from 56.9% to 97.2% 2, 3, 4, 5.
  • Factors such as healthcare access and insurance status have been found to impact shingles vaccination rates among older adults, but there is no mention of memory improvement as a benefit of the vaccine 6.

Vaccine Effectiveness and Safety

  • The vaccines have been found to be generally safe, with common adverse events including injection site pain, redness, and swelling, as well as systemic adverse events like myalgia, fatigue, and headache 2, 3, 4, 5.
  • The vaccines have been recommended for use in immunocompetent adults 50 years of age and older, with the Advisory Committee on Immunization Practices (ACIP) recommending the routine use of RZV as the preferred vaccine for preventing herpes zoster 4.

References

Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

Research

Vaccines for preventing herpes zoster in older adults.

The Cochrane database of systematic reviews, 2023

Research

Recombinant Zoster Vaccine (Shingrix): Real-World Effectiveness in the First 2 Years Post-Licensure.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2021

Research

Shingrix: The New Adjuvanted Recombinant Herpes Zoster Vaccine.

The Annals of pharmacotherapy, 2018

Research

Shingrix for Herpes Zoster: A Review.

Skin therapy letter, 2019

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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