Generic Name of Daflon
The generic name of Daflon is micronized purified flavonoid fraction (MPFF), which consists of 90% diosmin and 10% hesperidin 1, 2.
Key Information About the Formulation
Daflon is not a single chemical entity but rather a standardized combination of two flavonoid compounds:
- Diosmin (90%) - the primary active ingredient
- Hesperidin (10%) - the secondary flavonoid component
Both compounds are derived from citrus fruits and are processed through micronization (particles less than 2 microns) to enhance absorption 3.
Important Clinical Distinction
This is NOT the same as diclofenac sodium, despite the confusing FDA label information provided in reference 4 and 4. That appears to be a database error, as diclofenac is an NSAID with a completely different chemical structure and mechanism of action.
Clinical Applications
The MPFF formulation (Daflon 500 mg) is primarily used for:
- Chronic venous disease - treating symptoms like leg heaviness, pain, edema, and discomfort 5, 6
- Hemorrhoids - reducing bleeding and painful defecation 1
- Lymphedema management - improving venous tone and lymphatic drainage 1
Prescribing Considerations
Note that MPFF/Daflon has not been approved by the FDA for use in the United States 1. It is, however, widely available and used in Europe and other international markets. When prescribing or discussing this medication, refer to it by its generic composition (micronized purified flavonoid fraction or diosmin/hesperidin combination) rather than the brand name alone to avoid confusion with unrelated medications.