From the Guidelines
Yes, probenecid is available in the UK. It is marketed under the brand name Probenecid and is available as 500mg tablets. Probenecid is primarily used to treat gout and hyperuricemia by increasing the excretion of uric acid in the urine, thereby reducing uric acid levels in the blood. It can also be prescribed alongside certain antibiotics, particularly penicillins and cephalosporins, to increase their blood levels by reducing their renal excretion. In the UK, probenecid requires a prescription from a healthcare provider and is not available over-the-counter.
Key Points to Consider:
- The typical dosage for gout treatment is 250mg twice daily for the first week, then 500mg twice daily thereafter, though this may vary based on individual patient needs 1.
- Probenecid works by inhibiting the reabsorption of uric acid in the proximal tubules of the kidneys, which increases uric acid excretion and lowers serum uric acid levels.
- Patients should be aware that adequate fluid intake is important while taking this medication to reduce the risk of kidney stones.
- According to the 2020 American College of Rheumatology guideline for the management of gout, starting treatment with low-dose probenecid (500 mg once to twice daily) with subsequent dose titration is conditionally recommended 1.
- The 2012 American College of Rheumatology guidelines for management of gout also recommend probenecid as an alternative first-line pharmacologic ULT option, in the setting of contra-indication or intolerance to at least one XOI agent 1.
From the Research
Availability of Probenecid in the UK
- There is no direct evidence in the provided studies to confirm the availability of probenecid in the UK 2, 3, 4, 5, 6.
- However, the studies suggest that probenecid is used in various clinical applications, including the treatment of gout and as an adjunct to enhance blood levels of antibiotics 2, 3, 5.
- Probenecid has also been researched for its potential use in neuroprotection and as a tool for neuroinflammation 4, 6.
- The fact that probenecid is mentioned in studies related to its clinical applications and potential new uses suggests that it may be available in some countries, but its availability in the UK is not explicitly stated 2, 3, 4, 5, 6.
Clinical Applications of Probenecid
- Probenecid is used as a uricosuric agent in the treatment of chronic gout 2, 3, 5.
- It is also used as an adjunct to enhance blood levels of antibiotics, such as penicillins and cephalosporins 2, 3.
- Recent studies have explored its potential use in neuroprotection and as a tool for neuroinflammation 4, 6.