From the FDA Drug Label
2 DOSAGE AND ADMINISTRATION
2.1 Recommended Dosage The recommended dosage is 25 mg to 100 mg daily administered orally, in divided doses, depending upon clinical response.
1 INDICATIONS AND USAGE
Meclizine hydrochloride tablets are indicated for the treatment of vertigo associated with diseases affecting the vestibular system in adults.
The recommended use of Meclizine 12.5mg is not directly stated in the provided drug labels. However, the dosage range for treating vertigo is 25 mg to 100 mg daily. Since 12.5mg is below the recommended range, it is not clear if this dosage is effective for treating vertigo or motion sickness.
- The indicated dosage is between 25mg to 100mg daily.
- Meclizine is used for treating vertigo associated with diseases affecting the vestibular system in adults 1 1. The FDA drug label does not answer the question about the 12.5mg dosage.
From the Research
Meclizine 12.5mg should be taken 1 hour before travel for motion sickness, with doses of 12.5-25mg every 4-6 hours as needed, not exceeding 50mg in 24 hours, as supported by the most recent study 2. For vertigo, the usual dosage is 25-100mg daily, divided into smaller doses. Start with the lowest effective dose and adjust as needed under medical supervision. Meclizine works by blocking histamine receptors in the brain that trigger nausea and dizziness, while also reducing activity in the inner ear's balance center. Some key points to consider when using meclizine include:
- Side effects may include drowsiness, dry mouth, and blurred vision, so avoid alcohol and activities requiring alertness while taking it, as noted in 3.
- The medication typically starts working within an hour and effects can last 8-24 hours.
- Patients with glaucoma, prostate problems, or certain medical conditions should consult their doctor before use, as should pregnant or breastfeeding women.
- For best results, take meclizine consistently as prescribed and allow time for it to take effect before travel or activities that might trigger symptoms. It's also important to note that meclizine may not primarily work through sensory-specific mechanisms, but rather on a more central level, as indicated by 4. Additionally, meclizine has been shown to be equally effective as diazepam in the treatment of vertigo, according to 5. Overall, meclizine can be an effective treatment for motion sickness and vertigo, but it's essential to follow the recommended dosage and consult with a doctor if necessary.