Type 2 Diabetes Mellitus: This condition is characterized by insulin resistance, and unintentional weight loss can occur, especially if the disease is uncontrolled or if the patient has a significant increase in glucosuria, leading to a loss of calories.

Hyperthyroidism: An overactive thyroid gland can cause increased metabolism, leading to unintentional weight loss and worsening insulin resistance due to increased glucose production in the liver.
Chronic Infections (e.g., Tuberculosis): Chronic infections can lead to weight loss and may also contribute to insulin resistance through chronic inflammation.
Chronic Pancreatitis: Inflammation of the pancreas can lead to malabsorption and weight loss. It can also affect insulin production, worsening insulin resistance.

Pancreatic Cancer: Although less common, pancreatic cancer can cause unintentional weight loss and worsening insulin resistance due to its impact on pancreatic function, including insulin production.
HIV/AIDS: Unintentional weight loss is a common symptom, and insulin resistance can be exacerbated by the disease itself or by antiretroviral therapy.
Pituitary or Adrenal Gland Disorders (e.g., Cushing's Syndrome): These conditions can lead to significant metabolic changes, including insulin resistance and weight loss, depending on the specific disorder.

Lipodystrophy: A group of rare disorders characterized by the abnormal distribution of body fat, which can lead to insulin resistance and, in some cases, unintentional weight loss.
Prader-Willi Syndrome: A rare genetic disorder that can cause insulin resistance and significant weight gain, but in some cases, especially if not properly managed, can lead to unintentional weight loss.
Mitochondrial Disorders: Rare genetic conditions that affect the mitochondria and can lead to a variety of systemic symptoms, including insulin resistance and weight loss due to muscle weakness and decreased mobility.