Paxlovid Pack Contains 30 Tablets for Standard Dosing
A standard Paxlovid pack contains 30 tablets total, packaged in 10 blister cards, with each blister card containing 3 tablets (2 nirmatrelvir 150 mg tablets and 1 ritonavir 100 mg tablet). 1
Dosing Details
The normal dosage regimen is:
- 300 mg nirmatrelvir + 100 mg ritonavir taken together twice daily (morning and bedtime)
- This equals 3 tablets per dose (2 nirmatrelvir + 1 ritonavir)
- 6 tablets per day (3 tablets × 2 doses)
- 30 tablets total for the complete 5-day treatment course 1
Reduced Dose Pack for Renal Impairment
For patients with moderate renal impairment (eGFR 30-59 mL/min), a reduced-dose pack is available containing:
- 20 tablets total in 10 blister cards
- Each blister card contains 2 tablets (1 nirmatrelvir 150 mg + 1 ritonavir 100 mg)
- Dosing: 150 mg nirmatrelvir + 100 mg ritonavir twice daily for 5 days 2, 1
Clinical Context
The 5-day treatment course should be initiated within 5 days of symptom onset for maximum effectiveness in reducing hospitalization risk 2. The medication demonstrates a 39% relative risk reduction in hospitalization and 61% reduction in death risk, with particular benefit in patients aged 65+ years 3.
Important Caveat
Drug interactions are extremely common - 86.7% of patients have at least one clinically relevant interaction, primarily involving statins, immunosuppressants, and direct oral anticoagulants 4. Always check for contraindicated medications before prescribing, as ritonavir is a potent CYP3A4 inhibitor 2.