Invanz IM Reconstitution with Lidocaine
Reconstitute the contents of a 1 g vial of Invanz with 3.2 mL of 1.0% lidocaine HCl injection (without epinephrine) for intramuscular administration. 1
Reconstitution Protocol
The FDA-approved preparation method is straightforward:
- Volume: Add exactly 3.2 mL of 1.0% lidocaine HCl injection to the 1 g vial
- Lidocaine formulation: Must be without epinephrine
- Technique: Shake vial thoroughly to form solution
- Timing: Use the reconstituted IM solution within 1 hour after preparation 1
Administration Details
After reconstitution:
- Immediately withdraw the contents and administer by deep intramuscular injection
- Target large muscle masses (gluteal muscles or lateral thigh)
- Critical warning: The reconstituted solution should NOT be administered intravenously 1
Pediatric Dosing Considerations
For pediatric patients 3 months to 12 years of age:
- Use the same 3.2 mL of 1.0% lidocaine HCl for reconstitution
- Withdraw only the volume equal to 15 mg/kg of body weight (not to exceed 1 g/day)
- Discard the vial with unused portion of reconstituted solution 1
Important Safety Considerations
Contraindication: Due to the use of lidocaine HCl as a diluent, Invanz administered intramuscularly is contraindicated in patients with known hypersensitivity to local anesthetics of the amide type 1
The clinical tolerability of this formulation has been demonstrated, with ertapenem 1 g reconstituted in lidocaine showing comparable local tolerability to ceftriaxone when administered IM 2.