From the Research
Nicotinamide riboside chloride (NRCl) supplementation is generally well-tolerated, with no significant differences in adverse events reported between NR and placebo-treated groups, and no notable side effects were observed in the most recent and highest quality study 1.
Notable Side Effects
- The most recent study published in 2025 did not report any notable side effects of NRCl supplementation 2.
- Another recent study published in 2024 also did not report any significant side effects of NRCl supplementation 3.
- A study published in 2019 reported that there were no reports of flushing and no significant differences in adverse events between the NR and placebo-treated groups 1.
Potential Interactions
- NRCl may potentially interact with certain medications, particularly blood thinners and diabetes medications, by affecting blood glucose levels or enhancing the effects of anticoagulants.
Dosage and Administration
- Typical dosages of NRCl supplementation range from 250-500mg daily.
- Taking NRCl with food may help reduce gastrointestinal side effects.
- It is advisable to start with a lower dose and gradually increase to assess tolerance.
Mechanism of Action
- NRCl functions as a precursor to nicotinamide adenine dinucleotide (NAD+), a crucial molecule involved in cellular energy production and metabolic processes throughout the body.
- The body's adjustment to increased NAD+ levels may trigger temporary reactions, such as gastrointestinal symptoms or sleep disturbances.