Can a pilot take montelukast (singulair) and fly?

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Last updated: June 12, 2025View editorial policy

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From the Research

Pilots can generally take montelukast (Singulair) and continue flying, as it is typically considered acceptable for aviation duties. The FAA (Federal Aviation Administration) and most international aviation authorities allow the use of montelukast for pilots with proper medical certification. Montelukast is a leukotriene receptor antagonist used to treat asthma and allergies, and it's preferred over many other allergy or asthma medications because it doesn't cause drowsiness or impair cognitive function, as supported by studies such as 1.

Key Considerations

  • Pilots should take the medication as prescribed, typically 10mg once daily for adults, and should have their condition well-controlled before flying.
  • It's essential for pilots to inform their aviation medical examiner about all medications they're taking, including montelukast, during their medical certification examinations.
  • A pilot should allow for an observation period of at least 48 hours after starting the medication to ensure no adverse effects occur before resuming flight duties.
  • If any unusual side effects like mood changes or sleep disturbances develop, the pilot should ground themselves and consult their aviation medical examiner before flying again.

Evidence Summary

The use of montelukast in treating allergic rhinitis and asthma has been extensively studied, with evidence from 1 showing its efficacy and safety in patients with seasonal and perennial allergic rhinitis, with and without concomitant asthma. Montelukast's effectiveness as monotherapy and in combination with antihistamines, along with its favorable safety profile, makes it a viable option for pilots who require treatment for these conditions.

Recommendations

Given the evidence, pilots can safely take montelukast and fly, provided they follow the guidelines outlined above and consult with their aviation medical examiner. The medication's nonsedating properties and lack of significant cognitive impairment make it suitable for aviation duties, as noted in studies such as 2 and 3. However, it's crucial for pilots to prioritize their health and safety, as well as that of their passengers, by adhering to medical guidelines and reporting any adverse effects promptly.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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