Differential Diagnosis for Cryptogenic Organizing Pneumonia (COP)
Single most likely diagnosis
- Idiopathic Pulmonary Fibrosis (IPF): This is a common diagnosis to consider in patients with cryptogenic symptoms, as it can present with similar radiographic findings and symptoms such as cough and shortness of breath.
Other Likely diagnoses
- Connective Tissue Disease-Associated Interstitial Lung Disease: Conditions like rheumatoid arthritis, scleroderma, and lupus can cause interstitial lung disease with cryptogenic presentations.
- Hypersensitivity Pneumonitis: This condition, caused by an allergic reaction to inhaled substances, can present with similar symptoms and radiographic findings.
- Sarcoidosis: A systemic granulomatous disease that can affect the lungs and present with cryptogenic symptoms.
Do Not Miss
- Lymphangitic Carcinomatosis: A condition where cancer spreads to the lymphatic vessels in the lungs, which can present with similar symptoms and would be deadly if missed.
- Pulmonary Vasculitis (e.g., Wegener's Granulomatosis): Inflammatory conditions affecting the blood vessels in the lungs, which can have severe consequences if not diagnosed and treated promptly.
- Invasive Fungal Infections (e.g., Invasive Aspergillosis): Fungal infections that can affect the lungs and have high mortality rates if not diagnosed and treated early.
Rare diagnoses
- Eosinophilic Pneumonia: A rare condition characterized by the accumulation of eosinophils in the lungs, which can present with cryptogenic symptoms.
- Pulmonary Alveolar Proteinosis: A rare condition where the air sacs in the lungs fill with a type of protein, leading to respiratory symptoms.
- Lymphoid Interstitial Pneumonia: A rare condition characterized by the accumulation of lymphoid cells in the lungs, which can present with cryptogenic symptoms.