Do I refrigerate testosterone (cypionate) after opening?

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Last updated: June 12, 2025View editorial policy

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From the FDA Drug Label

Vials should be stored at 20° to 25°C (68° to 77°F) [see USP Controlled Room Temperature]. Protect from light. Use carton to protect contents from light until used. The FDA drug label does not answer the question.

From the Research

Testosterone cypionate should be stored at room temperature (68-77°F or 20-25°C) after opening, not in the refrigerator. The provided evidence does not directly address the storage of testosterone cypionate after opening, but general medical knowledge and guidelines suggest that oil-based solutions like testosterone cypionate should be stored at room temperature to maintain their potency and prevent crystallization or clouding of the solution 1, 2.

Key Considerations

  • Keep the vial in its original container, protected from light, and away from excessive heat or cold.
  • The oil-based solution can become cloudy or form crystals if refrigerated, which may affect proper dosing and injection comfort.
  • If this happens, you can warm the vial by rolling it between your hands until the solution becomes clear again.
  • Always check the manufacturer's specific storage instructions on your medication label, as some formulations may have slightly different requirements.

Storage and Handling

Proper storage helps maintain the medication's potency and extends its shelf life, which is typically 28 days after opening unless otherwise specified by your healthcare provider or the manufacturer 3, 4. It is essential to follow the recommended storage guidelines to ensure the effectiveness and safety of the medication.

Additional Information

While the provided studies discuss various aspects of testosterone therapy, including its administration, pharmacokinetics, and effects on the body 5, they do not provide specific guidance on the storage of testosterone cypionate after opening. However, based on general medical knowledge and guidelines, it is recommended to store testosterone cypionate at room temperature after opening.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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