From the Research
Africans are more prone to developing keloids due to genetic factors that influence collagen production and wound healing, with a prevalence estimated to be 6-16% in African populations, compared to less than 1% in Caucasian populations. This genetic predisposition causes an overproduction of collagen during the healing process, resulting in raised, thickened scars that extend beyond the original wound site 1. The exact genetic mechanisms aren't fully understood, but research suggests variations in certain genes related to fibroblast regulation and collagen synthesis play important roles 2.
Key Factors Contributing to Keloid Formation
- Genetic factors: Variations in genes related to fibroblast regulation and collagen synthesis contribute to keloid formation 2
- Environmental factors: Skin tension, wound location, and inflammation can influence keloid formation in genetically susceptible individuals
- Family history: Individuals with a family history of keloids are more likely to develop keloids themselves 1
Preventive Measures
- Avoiding elective surgeries or piercings in high-risk areas like the chest, shoulders, and earlobes
- Techniques to minimize tension on wound edges during surgery
- Post-operative treatments like silicone sheets, pressure therapy, or steroid injections may help reduce keloid formation 3, 4
Treatment Options
- Intralesional steroid injection: Triamcinolone acetonide (TAC) is the most commonly used intralesional corticosteroid for treating keloids 3
- Surgical excision: Often combined with intralesional steroid injection to reduce recurrence rates 5
- Laser therapy: May be used in combination with intralesional steroid injection to improve outcomes 3