How do I order sumatriptan nasal spray 11 mg?

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Last updated: October 21, 2026 • View editorial policy

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How to Order Sumatriptan 11mg Nasal Spray

Sumatriptan 11mg nasal powder is available as AVP-825 (brand name ONZETRA Xsail), which delivers 22mg total dose (11mg per nostril) and is the specific formulation you should order for this dose. 1

Ordering Information

The product you need is:

  • AVP-825 (ONZETRA Xsail): Sumatriptan nasal powder 22mg kit (delivers 11mg per nostril)
  • This is a breath-powered exhalation delivery system
  • Each dose consists of two 11mg nosepieces (one per nostril) for a total delivered dose of approximately 15-16mg sumatriptan intranasally 1

Alternative Nasal Formulations

If AVP-825 is not available, other intranasal sumatriptan options include:

  • Standard sumatriptan nasal spray: Available in 5mg, 10mg, and 20mg doses 2
  • DFN-02: Sumatriptan 10mg nasal spray with permeation enhancer 3

Note that there is no standalone "11mg" nasal spray formulation - the 11mg dose specifically refers to the AVP-825 delivery system where each nostril receives 11mg.

Clinical Context for Prescribing

According to current guidelines 4:

  • Intranasal triptans are appropriate for patients who cannot tolerate oral medications or have severe nausea/vomiting
  • Consider non-oral triptans when rapid onset is needed
  • The intranasal route provides faster absorption than oral but slower than subcutaneous administration 2

AVP-825 specifically provides earlier efficacy (within 30 minutes) compared to 100mg oral sumatriptan, with lower systemic exposure and predominantly mild, local side effects (abnormal taste, nasal discomfort). 1, 5

Prescribing Considerations

When ordering, specify:

  • Brand name (ONZETRA Xsail/AVP-825) or generic equivalent if available
  • Quantity needed (typically prescribed as individual treatment kits)
  • Ensure patient understands this is a breath-powered device requiring proper technique

The 20mg standard nasal spray has the best evidence for intranasal formulations (NNT 3.5) if AVP-825 is not accessible 2, though AVP-825 demonstrates superior early efficacy and consistency across multiple attacks 1.

References

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Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.