From the Research
Hyperbaric oxygen therapy (HBOT) should not be used as a standalone treatment for glioma, but it may be considered as an adjunctive therapy to enhance the effectiveness of standard treatments like radiation and chemotherapy, as suggested by the most recent study 1.
Effects of Hyperbaric Chamber on Glioma
The effects of hyperbaric oxygen therapy on glioma are still being researched, and the evidence is mixed. Some studies suggest that HBOT may improve the prognosis and reduce complications in glioma patients 2, 3, while others indicate that it may promote the growth of malignant glioma cells and inhibit cell apoptosis 4.
Mechanism of Action
HBOT involves breathing pure oxygen in a pressurized chamber, typically at 2.0-2.5 atmospheres absolute (ATA) for 60-90 minute sessions. The therapy works by increasing oxygen dissolution in blood plasma, allowing oxygen to reach oxygen-deprived tumor areas and potentially inhibiting tumor growth by reducing hypoxia-induced angiogenesis.
Potential Benefits and Risks
The potential benefits of HBOT for glioma patients include:
- Enhanced effectiveness of standard treatments like radiation and chemotherapy
- Reduced brain swelling (cerebral edema) around tumors, potentially improving neurological symptoms and quality of life The potential risks and side effects of HBOT include:
- Ear and sinus pain
- Temporary nearsightedness
- Claustrophobia
- Rarely, oxygen toxicity
- Patients with certain conditions like untreated pneumothorax or those taking specific medications like cisplatin should avoid HBOT due to potential complications.
Recommendation
Based on the most recent and highest quality study 1, HBOT may be considered as an adjunctive therapy to enhance the effectiveness of standard treatments like radiation and chemotherapy, but it should not be used as a standalone treatment for glioma. Patients should be aware of the potential benefits and risks of HBOT and discuss their individual situation with their healthcare provider.