From the Guidelines
Low-level laser therapy (LLLT) using a Flexbeam device with red light has been shown to be effective in promoting tissue repair and healing, particularly in the treatment of cutaneous leishmaniasis, with a reduction in lesion size of 67% and clearance of amastigotes in 94% of lesions after 8 weeks of treatment 1. The mechanism of action of LLLT involves the activation of mitochondria, increasing ATP production, improving blood circulation, and reducing inflammation.
- The Flexbeam device emits red light at wavelengths between 630-660nm, which penetrates the skin to stimulate cellular energy production.
- Typical sessions last between 10-20 minutes per treatment area, with recommended use of 3-5 times per week for optimal results.
- While the evidence is based on the treatment of cutaneous leishmaniasis, the underlying mechanism of action suggests potential benefits for tissue repair and healing in other conditions as well 1.
- It is essential to note that the evidence is not directly related to the use of Flexbeam devices, but rather to the use of red light in photodynamic therapy, which shares similar principles with LLLT.
- The device should not be used directly over the eyes, on open wounds, or by those with photosensitivity conditions or taking photosensitizing medications.
- Side effects are minimal but may include temporary skin warmth or redness.
- Results typically take 4-12 weeks of regular use to become noticeable.
From the Research
Effect of Low-Level Laser Therapy on Tissue Repair and Healing
- The use of low-level laser therapy (LLLT) has been shown to enhance tissue repair and healing through the process of photobiomodulation, which involves the absorption of red/near-infrared light energy by mitochondrial chromophores in skin cells 2, 3.
- This process leads to an increase in mitochondrial ATP production, cell signaling, and growth factor synthesis, as well as a reduction in oxidative stress, ultimately resulting in enhanced tissue repair and healing 2, 3.
- LLLT has been found to be beneficial in the treatment of various skin conditions, including wrinkles, acne scars, hypertrophic scars, and burns, as well as in the management of inflammatory diseases such as psoriasis and acne 3.
- The use of LLLT has also been shown to reduce UV damage and promote hair regrowth in individuals with androgenetic alopecia 4.
Mechanism of Action
- The mechanism of action of LLLT involves the absorption of photons by cellular photoreceptors, triggering chemical alterations and potential biochemical benefits to the human body 5.
- The absorption of red/near-infrared light energy by mitochondrial chromophores in skin cells leads to an increase in electron transport, adenosine triphosphate nitric oxide release, blood flow, reactive oxygen species increase, and diverse signaling pathways activation 3.
- This process ultimately results in enhanced tissue repair and healing, as well as a reduction in pain and inflammation 6, 5.
Clinical Applications
- LLLT has been found to be beneficial in the treatment of various musculoskeletal conditions, including non-specific knee pain, osteoarthritis, pain post-total hip arthroplasty, fibromyalgia, temporomandibular diseases, neck pain, and low back pain 6.
- The use of LLLT has also been shown to be effective in reducing pain intensity and promoting healing in individuals with chronic pain and osteoarthritis 5.
- LLLT is a non-invasive, safe, drug-free, and side-effect-free method for pain relief and tissue repair, making it a potentially significant addition to the armamentarium of healthcare providers 6, 4.