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Differential Diagnosis for Testicular Pain in a Non-Sexually Active Male

Single Most Likely Diagnosis

  • Epididymitis: This is an inflammation of the epididymis, a tube at the back of the testicle that stores and carries sperm. It is a common cause of testicular pain and can occur in non-sexually active males due to bacterial infections such as E. coli, often related to urinary tract infections.

Other Likely Diagnoses

  • Testicular torsion: Although more common in sexually active males, testicular torsion can occur in anyone. It is a condition where the spermatic cord becomes twisted, cutting off the blood supply to the testicle. It's a medical emergency.
  • Orchitis: Inflammation of one or both testicles, usually caused by bacterial or viral infections. It can be a cause of testicular pain in non-sexually active males, especially if related to viral infections like mumps.
  • Varicocele: An enlargement of the veins within the scrotum, similar to varicose veins. It can cause testicular pain and is more common on the left side.

Do Not Miss Diagnoses

  • Testicular cancer: Although rare, testicular cancer can present with testicular pain. Early detection is crucial for effective treatment, making it a diagnosis that should not be missed.
  • Appendicitis: In some cases, appendicitis can refer pain to the testicles, especially if the appendix is located near the testicles (retrocecal appendix).
  • Kidney stones: Pain from kidney stones can radiate to the groin and testicles, especially if the stone is moving down the ureter.

Rare Diagnoses

  • Henoch-Schönlein purpura (HSP): A form of vasculitis that affects blood vessels and can cause testicular pain among other symptoms like purpura, joint pain, and gastrointestinal symptoms.
  • Spermatocele: A cystic structure filled with sperm that arises from the head of the epididymis. It can cause testicular pain, though it's more commonly asymptomatic.
  • Cystic dysplasia of the testis: A rare congenital anomaly that can cause testicular pain and swelling.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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