From the Research
Yes, Myobloc (botulinum toxin type B) is typically used without dilution. Unlike other botulinum toxin products such as Botox or Dysport, Myobloc comes as a ready-to-use solution at a concentration of 5,000 units/mL and does not require reconstitution or dilution before administration. The pre-diluted formulation allows for direct withdrawal from the vial and immediate injection. This characteristic of Myobloc simplifies the preparation process and reduces the risk of dosing errors that might occur during reconstitution. However, it's essential to note that Myobloc has a more acidic pH (around 5.6) compared to other botulinum toxin products, which may cause more discomfort at the injection site, as seen in studies such as 1 where patients reported mild pain at the injection site. The solution should be stored in a refrigerator at 2-8°C (36-46°F) and should not be frozen. Once the vial is opened, the product should be used within 4 hours to maintain sterility and potency. Some key points to consider when using Myobloc include:
- Storage and handling to maintain potency and sterility
- Potential for discomfort due to its acidic pH
- Direct injection without need for dilution, simplifying the administration process
- Efficacy in treating glabellar rhytides and other facial lines, as demonstrated in studies like 2 and 1. Given the information from the most recent and highest quality studies, such as 1, the use of Myobloc without dilution is recommended for the treatment of glabellar wrinkles and other facial rhytides, considering its efficacy, safety profile, and the practical advantages it offers over other botulinum toxin products.