Estratest Estrogen Content
Estratest contains either 1.25 mg or 0.625 mg of esterified estrogens per tablet, depending on the formulation. 11
Available Formulations
Estratest comes in two distinct strengths:
Estratest F.S. (Full Strength)
- 1.25 mg of esterified estrogens per tablet
- Combined with 2.5 mg of methyltestosterone
- Light green, oval-shaped tablet marked with "640" 11
Estratest H.S. (Half Strength)
- 0.625 mg of esterified estrogens per tablet
- Combined with 1.25 mg of methyltestosterone
- Dark green, oval-shaped tablet marked with "639" 11
Composition Details
The esterified estrogens in Estratest are a mixture of sodium salts of sulfate esters of estrogenic substances, primarily estrone, similar to those excreted by pregnant mares. The formulation contains 75-85% sodium estrone sulfate and 6-15% sodium equilin sulfate, with these two components totaling at least 90% of the mixture. 1
Clinical Context
These doses represent systemic estrogen therapy levels. For reference, the 2015 Endocrine Society guidelines note that starting doses for menopausal hormone therapy are generally lower than historical standards, with the principle of using the lowest effective dose. 2 The 1.25 mg dose in Estratest F.S. matches the higher end of typical systemic estrogen dosing, while the 0.625 mg in Estratest H.S. represents a moderate systemic dose.