Rexulti Does Not Increase Blood Pressure
Rexulti (brexpiprazole) actually causes decreased blood pressure (orthostatic hypotension), not increased blood pressure. According to the FDA drug label, one of the serious side effects of Rexulti is "decreased blood pressure (orthostatic hypotension) and fainting," where patients may feel dizzy, lightheaded, or pass out when rising too quickly from sitting or lying positions 1.
Key Blood Pressure Effects of Rexulti
The FDA labeling explicitly warns about hypotension as a risk, not hypertension:
- Orthostatic hypotension is listed as a serious adverse effect requiring monitoring
- Patients may experience dizziness and falls related to blood pressure drops when changing positions
- The medication can cause "changes in your pulse, blood pressure, heart rate, and breathing" as part of neuroleptic malignant syndrome (a rare but serious condition) 1
Important Clarification About Your Question
Your question appears to confuse Rexulti with thyroid medications. The expanded context mentions "levothyroxine and liothyronine," but Rexulti contains brexpiprazole, an atypical antipsychotic used for:
- Adjunctive treatment of major depressive disorder in adults
- Treatment of schizophrenia in adults and children ≥13 years
- Treatment of agitation associated with Alzheimer's dementia 1
Blood Pressure Monitoring Recommendations
While taking Rexulti:
- Monitor for orthostatic symptoms - particularly dizziness upon standing
- Use caution in elderly patients who are at higher risk for falls related to blood pressure drops
- Rise slowly from sitting or lying positions to minimize orthostatic hypotension risk
- The medication does not require routine blood pressure monitoring for hypertension, but rather awareness of hypotensive episodes 1
Common pitfall: Confusing Rexulti with thyroid replacement therapy. If you're asking about levothyroxine's effects on blood pressure, that's a completely different medication with different cardiovascular effects (levothyroxine can actually help reduce blood pressure in patients with subclinical hypothyroidism 2, 3).