Differential Diagnosis for Hydromorph and Itchy

• Single most likely diagnosis
  • Contact dermatitis: This is a common condition that can cause itchiness and skin lesions, possibly related to hydromorphone (Hydromorph) use or other environmental factors.
• Other Likely diagnoses
  • Allergic reaction: An allergic reaction to hydromorphone or another substance could cause itchiness and skin symptoms.
  • Dry skin (xerosis): This condition can cause itchiness, especially in patients taking certain medications like opioids.
  • Urticaria: Hives can be itchy and may be related to an allergic reaction or other factors.
• Do Not Miss (ddxs that may not be likely, but would be deadly if missed.)
  • Anaphylaxis: A severe, life-threatening allergic reaction that requires immediate medical attention.
  • Stevens-Johnson syndrome: A rare but serious condition that can cause skin lesions, itchiness, and other symptoms.
  • Opioid-induced histamine release: Some opioids, including hydromorphone, can cause histamine release, leading to itchiness and other symptoms.
• Rare diagnoses
  • Erythromelalgia: A rare condition characterized by burning pain, heat, and redness in the hands and feet, which can be associated with itchiness.
  • Polycythemia vera: A rare blood disorder that can cause itchiness, especially after warm baths or showers.
  • Cholestasis: A condition characterized by reduced bile flow, which can cause itchiness and other symptoms.