From the Guidelines
Yes, atomoxetine (Strattera) capsules can be opened and mixed with applesauce for administration. The contents of the capsule should be sprinkled entirely onto a small amount of applesauce and consumed immediately without chewing, as stated by the manufacturer [Eli Lilly and Company, 2020@]. It's essential to consume the entire mixture to ensure the full dose is taken, and the mixture should not be stored for later use. This method of administration can be helpful for individuals who have difficulty swallowing capsules whole, such as children or those with swallowing difficulties.
Key Administration Considerations
- The entire contents of the capsule should be sprinkled onto a small amount of applesauce
- The mixture should be consumed immediately without chewing
- The entire mixture must be consumed to ensure the full dose is taken
- The mixture should not be stored for later use
- A small amount of applesauce is recommended to mask the bitter taste of the medication Opening the capsule does not affect the medication's properties because atomoxetine is not formulated as an extended-release medication - the drug's effectiveness comes from its active ingredient rather than a special capsule design [@1@]. However, it is crucial to follow the recommended dosage and administration guidelines to minimize the risk of adverse effects, such as nausea, vomiting, fatigue, decreased appetite, abdominal pain, and somnolence, which are commonly reported in clinical trials [@1
From the FDA Drug Label
Atomoxetine capsules are not intended to be opened, they should be taken whole [see Patient Counseling Information (17)]. Atomoxetine hydrochloride is an ocular irritant. Atomoxetine capsules are not intended to be opened. In the event of capsule content coming in contact with the eye, the affected eye should be flushed immediately with water, and medical advice obtained.
No, atomoxetine capsules should not be opened and mixed with applesauce, as they are not intended to be opened. This is stated in the drug label to ensure safe use and handling of the medication.
From the Research
Atomoxetine Capsules and Applesauce
- Atomoxetine (Strattera) capsules are designed to be taken whole, and there is limited information available on the effects of opening them and mixing with applesauce 1.
- However, a study on crushing tablets or opening capsules warns that this practice can have serious clinical consequences, including altered drug absorption, overdose, or underdosing 2.
- There is no specific information available on the safety and efficacy of opening atomoxetine capsules and mixing with applesauce, but it is generally recommended to avoid altering the dosage form of medications without consulting a healthcare professional.
- Atomoxetine is a selective norepinephrine reuptake inhibitor, and its mechanism of action, clinical efficacy, and safety have been well-studied 3, 4, 5.
- The medication can be administered as a single daily dose or split into two evenly divided doses, and it has a negligible risk of abuse or misuse 1, 3.
- However, the decision to open atomoxetine capsules and mix with applesauce should be made on a case-by-case basis, taking into account the individual patient's needs and medical history, and under the guidance of a healthcare professional.