From the Guidelines
Rupall dosing should be based on weight, with adults receiving 15 mg/kg once daily (oral) or 25 mg/kg three times per week (oral), depending on the treatment regimen, as recommended by the British Thoracic Society guidelines 1. The dosing for Rupall, possibly referring to a medication such as ethambutol, is crucial for effective treatment.
- For adults, the recommended dose is 15 mg/kg once daily (oral) or 25 mg/kg three times per week (oral) 1.
- It's essential to round the dose up or down to the closest whole number of tablets.
- The dosage for children (1 month to 18 years) is 20 mg/kg once daily (oral), with doses rounded down to facilitate administration of suitable volumes of liquid or an appropriate strength of tablet 1. When calculating the ideal body weight for dosing, the following formulas can be used:
- Male ideal body weight (kg) = 50 + (2.3 × height in cm above 152.4)/2.54
- Female ideal body weight (kg) = 45.5 + (2.3 × height in cm above 152.4)/2.54 It's crucial to note that ethambutol should be dosed on lean body weight, as stated in the British Thoracic Society guidelines 1. The guidelines do not provide information on the specific medication "Rupall," but based on the context, it appears to be related to ethambutol or another medication used in the treatment of non-tuberculous mycobacterial pulmonary disease (NTM-PD) 1. In contrast, the American Thoracic Society/Centers for Disease Control and Prevention/Infectious Diseases Society of America clinical practice guidelines for drug-susceptible tuberculosis provide dosing information for various antituberculosis drugs, but do not mention "Rupall" explicitly 1. However, the guidelines do provide information on the dosing of ethambutol, which is consistent with the recommendations from the British Thoracic Society guidelines 1. Therefore, the recommended weight-based dosing for Rupall, as per the British Thoracic Society guidelines, should be followed to ensure effective treatment and minimize potential side effects 1.
From the Research
Weight-Based Dosing for Rupall
- The proper weight-based dosing for Rupall is unclear as the exact medication is not specified.
- However, studies have shown that weight-based dosing can be challenging due to poor awareness and adherence 2.
- The applicability of weight-based dosing depends on various factors such as clinical indications, physiological factors, and types of medication 2.
- In some cases, weight-based dosing may be superior to fixed-dose regimens, while in other cases, fixed dosing may be non-inferior or even better 2.
- Ideal body-weight-based dosing may be superior to total body-weight-based dosing for certain medications 2, 3.
- Effective weight-based dosing interventions include standardization of weight estimation, documentation and dosing determination, dosing charts, and educational measures 2.
Considerations for Weight-Based Dosing
- Obesity can affect medication dosing, and using ideal body weight or adjusted body weight may provide more effective dosing 3, 4.
- Dosing based on total body weight may not always be appropriate, especially in obese patients 3, 4.
- Alternate weight descriptors such as ideal body weight, adjusted body weight, fat-free weight, and lean body weight can be used to prevent drug overexposure with weight-based dosing 4.
- Pharmacy-level stewardship strategies, such as dose rounding and vial sharing, can also reduce cancer drug spending when combined with weight-based dosing 5.
Medication Adherence
- Medication adherence is crucial for the success of treatment, and non-adherence can be costly for the health service 6.
- Factors affecting medication adherence include intentional or non-intentional non-adherence, and interaction with health professionals can promote adherence 6.
- Aids such as dosing charts and educational measures can also help improve medication adherence 2, 6.