From the Guidelines
The recommended dosage of diphenhydramine (Benadryl) for children is 1 to 2 mg/kg per dose, with a maximum dose of 50 mg IV or oral, as stated in the most recent and highest quality study 1.
Important Considerations
- The dosage may vary depending on the child's age and weight.
- Diphenhydramine should not be given to infants under 2 years without medical supervision due to potential serious side effects.
- The medication works by blocking histamine receptors, reducing allergic symptoms like itching, sneezing, and runny nose.
- Side effects may include sedation, dry mouth, and in some children, paradoxical excitability.
Administration Guidelines
- Use the measuring device provided with the medication for accuracy.
- Be aware that diphenhydramine causes drowsiness, which is why it's often used at bedtime for allergies.
- Always consult a healthcare provider before giving any medication to children, especially for those with medical conditions or taking other medications.
Key Points to Remember
- The maximum dose of diphenhydramine for children is 50 mg IV or oral.
- Alternative dosing may be with a less-sedating second-generation antihistamine.
- Diphenhydramine is not a first-line treatment for anaphylaxis, but it can be used as an adjunctive treatment.
From the FDA Drug Label
Directions • take every 4 to 6 hours, or as directed by a physician• do not take more than 6 doses in 24 hours agedose Adults and children over 12 years of age10 mL (25 mg) to 20 mL (50 mg) Children 6 to under 12 years of age10 mL (25 mg) Children under 6 years of ageDo not use
The recommended dosage of diphenhydramine (Benadryl) for children is:
- Children 6 to under 12 years of age: 10 mL (25 mg) every 4 to 6 hours, not to exceed 6 doses in 24 hours.
- Children under 6 years of age: Do not use.
- Children over 12 years of age: 10 mL (25 mg) to 20 mL (50 mg) every 4 to 6 hours, not to exceed 6 doses in 24 hours 2.
From the Research
Dosage of Diphenhydramine (Benadryl) for Children
There are no specific studies provided that directly address the recommended dosage of diphenhydramine (Benadryl) for children. However, the following points can be considered:
- The studies provided do not offer guidance on the dosage of diphenhydramine for children, but rather discuss its use, side effects, and comparisons with other antihistamines 3, 4.
- One study mentions the use of antihistamines in the management of anaphylaxis, but does not provide specific dosage information for diphenhydramine in children 5.
- Another study discusses the dosing and antipyretic efficacy of oral acetaminophen in children, but this is not relevant to diphenhydramine dosage 6.
- A study on the evaluation of the mRNA-1273 vaccine in children 6 months to 5 years of age provides information on vaccine dosage and safety, but is not related to diphenhydramine dosage 7.
Key Points to Consider
- The provided studies do not offer specific guidance on the recommended dosage of diphenhydramine for children.
- Diphenhydramine is discussed in the context of its use, side effects, and comparisons with other antihistamines, but dosage information for children is not provided 3, 4.
- It is essential to consult a healthcare professional or a reliable medical resource for guidance on the appropriate dosage of diphenhydramine for children.