From the Research
The management of Grover's disease (transient acantholytic dermatosis) should focus on symptom relief, with first-line treatment including topical corticosteroids, as the condition often resolves spontaneously within 6-12 months. The goal of treatment is to reduce inflammation and itching, while also preventing triggers that can worsen symptoms. According to the most recent and highest quality study 1, topical corticosteroids (TCSs) have a response rate of 70%, making them the most frequently employed treatment.
Some key points to consider in the management of Grover's disease include:
- Topical corticosteroids such as triamcinolone 0.1% cream applied twice daily to affected areas for 2-4 weeks to reduce inflammation and itching 1
- Antihistamines such as cetirizine 10mg daily or hydroxyzine 25mg three times daily to help control pruritus
- Keeping the skin cool and dry, as heat and sweating often trigger or worsen symptoms
- Avoiding hot showers, using mild soaps, applying moisturizers after bathing, and wearing loose cotton clothing
- Considering oral retinoids like acitretin (25-50mg daily) or isotretinoin (0.5mg/kg/day) for 2-3 months for persistent cases, as they have a response rate of 86% 1
- Phototherapy with UVB or PUVA can also be effective for widespread disease
It's essential to note that the exact cause of Grover's disease remains unclear, but heat, sweating, and sun exposure are known triggers that should be minimized during treatment 2, 1. By prioritizing symptom relief and preventing triggers, patients with Grover's disease can effectively manage their condition and improve their quality of life.