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Last updated: June 13, 2025View editorial policy

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Differential Diagnosis for Scrotum Pain

  • Single most likely diagnosis
    • Epididymitis: This is the most common cause of scrotal pain, especially in young men. It is usually caused by a bacterial infection and presents with pain, swelling, and tenderness of the epididymis.
  • Other Likely diagnoses
    • Orchitis: Inflammation of one or both testicles, often caused by bacterial or viral infections, which can lead to scrotal pain.
    • Testicular torsion (early stages): Although it's a medical emergency, in its early stages, it might not present with the classic severe pain and can be mistaken for other conditions.
    • Hydrocele: A condition where fluid accumulates in the scrotum, causing swelling and discomfort, which can sometimes be painful.
    • Varicocele: Enlargement of the veins within the scrotum, similar to varicose veins, which can cause aching or discomfort.
  • Do Not Miss (ddxs that may not be likely, but would be deadly if missed)
    • Testicular torsion (advanced stages): A medical emergency that requires immediate attention. If missed, it can lead to loss of the testicle and potentially long-term fertility issues.
    • Testicular cancer: Although less common, it's crucial to consider, especially in men with a history of undescended testes or family history of testicular cancer.
    • Fournier's gangrene: A rare but life-threatening condition characterized by necrotizing fasciitis of the genitalia, which can start with scrotal pain and progress rapidly.
  • Rare diagnoses
    • Spermatocele: A cystic structure filled with sperm that arises from the head of the epididymis, which can cause discomfort or pain.
    • Scrotal cellulitis: A bacterial infection of the skin and subcutaneous tissue of the scrotum, which can cause pain, redness, and swelling.
    • Henoch-Schönlein purpura (HSP): A form of vasculitis that can affect the scrotum, among other areas, and cause pain and swelling.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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