From the Research
Cefotaxime is marketed under several brand names, with Claforan being the most common brand name in the United States and many other countries. Cefotaxime is a third-generation cephalosporin antibiotic used to treat various bacterial infections, including those affecting the respiratory tract, urinary tract, skin, bones, joints, and meningitis. It works by inhibiting bacterial cell wall synthesis, leading to cell death. The medication is typically administered via injection (intravenous or intramuscular) and is not available in oral form. Dosing varies based on the type and severity of infection, patient's age, weight, and kidney function, typically ranging from 1-2 grams every 8-12 hours for adults with normal renal function. Other brand names for cefotaxime in different markets include Cefotax, Oritaxim, and Taxime, though availability varies by country and region. This medication requires a prescription and should only be used under medical supervision, as supported by studies such as 1.
Some key points to consider when prescribing cefotaxime include:
- The effectiveness of cefotaxime in treating bacterial meningitis, as compared to other antibiotics like ceftriaxone, has been studied in several trials, including 2 and 3.
- High doses of cefotaxime may be necessary to treat certain infections, such as those caused by Streptococcus pneumoniae with decreased susceptibilities to broad-spectrum cephalosporins, as seen in 4.
- The clinical efficacy of cefotaxime has been evaluated in various patient populations, including those with underlying diseases, as reported in 5.
- It is essential to monitor patients for potential adverse reactions and adjust the dosage accordingly, considering factors such as renal function and age.
Overall, cefotaxime is a valuable antibiotic for treating various bacterial infections, and its brand names, including Claforan, are widely recognized and used in clinical practice.